Thursday, March 26, 2009
Diabetes Mellitus [type 2] Diet Menu plan and Guidelines
Wednesday, March 25, 2009
Leading a Heart Healthy Lifestyle is Important For Women of Every Age( cuer for heart disease,cholestrol,diabetes,blood pressure)
Long considered a man's problem, heart disease now affects more female than males. Heart disease is responsible for 52 percent of all deaths in American women, claiming 250,000 female lives every year - more than all forms of cancer. Fortunately, much is known today about preventing and monitoring heart disease through lifestyle changes, which makes it possible to control many of your risk factors. To begin leading a heart healthier lifestyle, you first need to better understand heart disease. What is heart disease? Heart disease is the term used to describe a number of ailments affecting the heart, blood vessels and arteries. These conditions include: Coronary Artery Disease - also referred to as coronary heart disease, this is a disease caused by fat, cholesterol and plaque build-up inside the artery walls, making them narrow. Coronary artery disease occurs when the heart does not get the oxygen and nutrients that it needs to function properly because of decreased blood flow. Valvular Heart Disease - a disease that occurs when any of the four heart valves is damaged and becomes leaky (incompetent) , causing backflow of blood when the valve should be closed, or narrowed (stenosis), which makes it difficult for blood to flow forward. Congestive Heart Failure - a condition caused by a variety of other conditions - including high blood pressure, coronary artery disease and valvular heart disease - that develops when the heart cannot adequately pump blood through the body. What is your risk for heart disease? It is important to understand the risk factors that impact your likelihood of developing heart disease. Luckily, many of these factors are within your control. Answering the following questions and assessing your own risk for heart disease is the first step toward a heart healthy lifestyle. Do you have a family history of early heart disease? The tendency toward certain heart disease risk factors may be inherited. The presence of an immediate female family member (mother or sister) with coronary heart disease before age 65, or male relative (father or brother) diagnosed before age 55, will significantly increase your risk of heart disease. Do you have high blood pressure? High blood pressure makes the heart work harder, contributes to hardening of the arteries, and increases the frequency of angina (chest pain that is the heart's response to a lack of oxygen), as well as the risk of heart attack and stroke. Do you have high cholesterol? High levels of cholesterol in the blood lead to increases in the amount of plaque in the arteries and coronary artery disease. All adults should have a lipid profile performed including a total cholesterol, LDL, HDL, and triglyceride levels. This is done after fasting for eight hours in order to get the most accurate results. The newest guidelines provide targets for your lipids according to your risk factor profile. Do you have diabetes? Diabetes, especially uncontrolled or untreated - can significantly increase your risk of heart disease. A simple blood test can determine how much glucose (sugar) is in your blood. The normal, non-diabetic range for fasting blood glucose is from 70 to 100 mg/dL. If the level is over 126mg/dL, it usually means you have diabetes. If you have diabetes, treating other risk factors for cardiovascular disease - such as hypertension and abnormal cholesterol levels - is particularly important. Have your menstrual periods stopped? As women reach menopause, the risks increase with one in 10 women between the ages of 45 and 64 experiencing some form of heart disease. After age 65, that statistic jumps to one in four. Around menopause, estrogen levels start to drop, and heart disease risk starts to rise. Do you smoke? If you smoke, kick the habit! Smoking increases your risk for a heart attack by almost five times that of a non-smoker. In addition, it has been found that low-tar cigarettes are not effective in reducing the risk of heart disease in those people who use tobacco. Are you more than 20 pounds overweight? Being overweight can more than double your risk of heart disease. Obesity increases the risk of high blood pressure, diabetes and abnormal cholesterol levels. Do you get little or no regular exercise? Studies suggest regular exercise can significantly reduce your risk of heart disease. Physical activity lowers your blood pressure, increases the amount of "good" cholesterol in your blood and reduces the tendency of blood to clot. Aerobic exercise - any exercise that makes the heart and lungs work harder to supply the muscles with oxygen - is a great way to strengthen your heart. What is your body shape? Depending on your body type, whether you are apple- or pearshaped, you may be more likely to develop heart disease. The Nurses' Health Study at Brigham and Women's Hospital found that middle-aged and older women who are apple-shaped are at greater risk for heart disease. According to the study, women with a 38-inch waist or greater are three times more likely to develop coronary heart disease than women with waistlines of 28 inches or less. Make a healthy change As a woman, it is important for you to understand heart health. Current research studies, such as the Nurses' Health Study at Brigham and Women's Hospital (http://www.brighama ndwomens. org/excellence/ cardiovascular. aspx), are finding significant differences between men and women that extend to the symptoms, prevention and treatment of heart disease. Be heart smart for your good health! About The Author: As a woman, it is important for you to understand heart health. Current research studies, such as the Nurses' Health Study at http://www.brighama ndwomens. org/excellence/ cardiovascular. aspx Brigham and Women's Hospital, are finding significant differences between men and women that extend to the symptoms,prevention and treatment of heart disease. Be heart smart for your good health! Please use the HTML version of this article at: http://www.isnare. com/html. php?aid=289053 ============ ====== ARTICLE END ============ ====== For more free-reprint articles by Paulette Bouchard please visit: http://www.isnare. com/?s=author& a=Paulette+ Bouchard |
Sunday, March 22, 2009
The Dangers of 'Hidden' Kidney Disease,dialysis,transplant,cleanse
Sunday, February 22, 2009
Kalmegh - the wonder herb!

Andrographis
Scientific Name(s): Andrographis paniculata (Burm.f.) Wall. Nees. Family: Acanthaceae
Common Name(s): Kalmegh (Hindi), Kalmegha (Snaskrit), Chuanxinlian (Chinese), Kalupnath , Kirayat (Hindi), Mahatita (King of Bitters), Alui , Bhunimba , Bhui-neem , Yavatikta (Sanskrit), Sam biloto (Malay)
Clinical Overview
Uses of Andrographis
Kalmegh has been used for liver complaints and fever, and as an anti-inflammatory and immunostimulant. In clinical trials, Andrographis extract has been studied for use as an immunostimulant in upper respiratory tract infections and HIV infection. The potential of andrographolide as an anticancer agent is being investigated. However, clinical evidence to support the use of Kalmegh for any indication is lacking.
Andrographis Dosing
The usual daily dose of andrographolides for common cold, sinusitis, and tonsillitis is 60 mg. Doses of 10 mg/kg resulted in the discontinuation of a clinical trial because of adverse reactions. Clinical trials in children with upper respiratory tract infection reported the use of andrographolide 30 mg daily for 10 days.
Contraindications
Contraindications have not been identified.
Pregnancy/Lactation
Documented adverse reactions. Abortifacient. Avoid use.
Andrographis Interactions
None well documented.

Andrographis Adverse Reactions
Headache, fatigue, rash, bitter/metallic taste, diarrhea, pruritus, and decreased sex drive were reported in 1 clinical trial. One HIV-positive participant experienced an anaphylactic reaction. Doses used in this trial were 10 mg/kg body weight.
Botany
A. paniculata is an erect annual herb that grows 30 to 110 cm in height and is native to India, China, and Southeast Asia. It is widely cultivated in Asia. The square stem has wings on the angles of new growth and is enlarged at the nodes, while small white flowers with rose-purple spots are borne on a spreading panicle. The plant produces yellowish-brown seeds, and all parts have an extremely bitter taste. The portion of the plant appearing above ground are harvested in the fall. The genetic variability of the species has been examined. 1 , 2
History
A. paniculata has been used for centuries in India, China, Thailand, and other Asian countries and is present in 26 different polyherbal formulations in the Ayurvedic traditional health system. Kalmegh is listed in the 1992 Pharmacopoeia of the Peoples Republic of China as a cold property herb used to rid the body of fevers and dispel toxins. An immunostimulant preparation known as Kan Jang , which contains Kalmegh and eleutherococcushas, been used in Scandinavian countries for 20 years. Kalmegh is also manufactured and marketed in the United States. 3 , 4 , 5
Chemistry
The diterpene lactone andrographolide was first isolated as a major constituent 6 and later characterized as a lactone. 7 , 8 Its full structure was determined in the 1960s, 9 , 10 and x-ray crystallography later confirmed the structure. 11 A number of related minor diterpenes and their glycosides have since been identified. 5 , 12 , 13 , 14 , 15 , 16 , 17 , 18 Methods of analysis, including high-pressure liquid chromatography and nuclear magnetic resonance, 19 have been published. A method for rapid isolation of andrographolide is also available. 20 When callus cultures of the plant were investigated, andrographolide and the other diterpenes were not produced. Instead, the sesquiterpenes paniculides A-C were found. 21 Other constituents of the plant include various flavones. 18 , 22

Andrographis Uses and Pharmacology
Antimicrobial
Extracts of Andrographis and andrographolide derivatives have shown modest activity in vitro against HIV 18 , 23 , 24 , 25 , 26 ; however, a phase 1 study of andrographolide showed no effect on viral replication after 6 weeks, despite increased CD4 counts. 27
Activity in antimalarial screens has also been noted for Andrographis extracts, but clinical trials are lacking. 28 , 29 , 30
The extract of A. paniculata blocked Escherichia coli enterotoxin-induced secretion in rabbit and guinea pig models of diarrhea. 31 Andrographolide and 3 other related diterpenes were responsible for this action. 32 Other in vitro experiments present conflicting results for the action of andrographolide and leaf extracts on E. coli . 33 , 34
Cancer
Animal and in vitro experiments using human cancer cell lines to investigate the potential anticancer effects of A. paniculata have found andrographolide responsible for the observed effects rather than other diterpenes. 5 , 35 , 36 Various mechanisms of action have been proposed, including enhancement of chemokine activity, inhibition of tumor-specific angiogenesis affecting cell cycle progression, and induction of apoptosis. 35 , 36 , 37 , 38 Cancer cell lines investigated include prostate, breast, cervical, colon, hepatoma, melanoma, and lymphocytic leukemia. Researchers are now focusing on synthesizing compounds based on andrographolide to improve selectivity and potency. 35 , 39
The need for caution has been raised by one group of researchers because andrographolide-enhanced SDF-1-chemokine activity might induce tumor cell metastasis. 38 A. paniculata extract has also induced cell differentiation in mouse myeloid leukemia cells. 40
Animal data
Both antigen-specific and antigen-nonspecific immune responses in mice were stimulated by andrographolide and an ethanolic extract; the extract was more potent than andrographolide, suggesting that other constituents also were immunostimulants. 41 Inhibition of passive cutaneous anaphylaxis and mast cell stabilization was observed in studies of the purified diterpenes in rats. 42
Clinical data
A systematic review of 4 clinical trials found A. paniculata , either alone or in a fixed combination with A. senticosus ( Kan Jang ), significantly more effective than placebo ( P < p =" 0.0002,">
A small study in patients with familial Mediterranean fever (Nߙ=ߙ24) found a decrease in frequency, duration, and severity of febrile attacks, compared with placebo. 46
Stimulation of the production of key cytokines and immune activation markers has been investigated as potential mechanisms of andrographolide immunomodulation. 4 , 38 , 47
Extracts of Andrographis have demonstrated hypoglycemic action in rats with streptozotocin- and alloxan-induced diabetes, supporting a traditional use of Kalmegh. 18 , 48 , 49 Clinical trials are lacking.
Two older trials explored a possible hypotensive effect of andrographolide/Kalmegh, but further investigation has not been conducted. 50 , 51
Animal experiments suggest that the extract of A. paniculata is hepatoprotective, 52 , 53 , 54 but clinical trials are lacking. Hepatic drug-metabolizing enzymes were elevated in 1 animal experiment, 54 however, in a clinical trial, elevated liver enzymes (AST and ALT) were reported. 27
Andrographolide has demonstrated anti-inflammatory effects in several cellular systems, including prevention of phorbol ester-induced reactive oxygen species and N-formyl-methionyl-leucyl-phenylalanine-induced adhesion in rat neutrophils, 55 , 56 inhibition of tumor necrosis factor-induced upregulation of intercellular adhesion molecule expression, and monocyte adhesion 57 and activation of protein kinase pathways. 58
Dosage
Kalmegh dosage in clinical studies has ranged from 3 to 6 g of the crude plant.
The usual daily dose of andrographolides for common cold, sinusitis, and tonsillitis is 60 mg, 59 , 60 but doses up to 1,200 mg have been reported. 61 Andrographolide 48 mg daily was used in a trial of familial Mediterranean fever. 46 Doses of 5 to 10 mg/kg were used in a trial in HIV patients, but adverse reactions at this dosage stopped the trial. 27
Clinical trials in children with upper respiratory tract infection reported the use of andrographolide 30 mg daily for 10 days. 45
Adverse Reactions
Research reveals few adverse reactions reported with the use of A. paniculata . However, adverse reactions (eg, headache, fatigue, rash, bitter/metallic taste, diarrhea, pruritus, decreased sex drive) during a phase 1 study of andrographolide in HIV required interruption of the trial. One HIV-positive participant experienced an anaphylactic reaction. Doses of andrographolide 10 mg/kg body weight were used when the adverse reactions became apparent. 27 In the same trial, elevated liver enzymes were experienced by many of the participants. Two cases of urticaria have been reported in other trials. 43
Toxicology
Toxicology studies are limited, but Kalmegh does not appear to be acutely toxic. Acute lethal doses (median lethal dose) in mice are reported to be more than 40 g/kg for andrographolide. 27

Male reproductive toxicology of Andrographis has been studied. A subchronic 60-day study in male rats showed no changes in testicular weight, histology, or testosterone levels. 63 However, detailed studies in rats given purified andrographolide for 48 days showed decreases in sperm counts and motility that were linked to disruption of spermatogenesis. 64
A small, short-duration, phase 1 clinical trial in healthy men found no negative effects at doses 3 times the usual daily dose of Kan Jang . Instead, a positive trend in the number of spermatozoids, percent active forms, and fertility indexes was found. Limitations of the study included the small number of participants (N = 14), the short duration of the study (10 days), and the low dose tested (3 times the normal dose versus 10-fold in animal studies). 59




